POS-060 CHRONIC KIDNEY DISEASE IN PEDIATRIC ACUTE KIDNEY INJURY SURVIVORS FROM INTENSIVE CARE UNIT: PROSPECTIVE STUDY FROM A DEVELOPING COUNTRY

Acute kidney injury (AKI) is an independent risk factor for mortality in critically il. Incidence of AKI PICU ranges from 8-30%. Despite advances therapy, still high and survivors are at CKD. A hospital based prospective cohort study was conducted on ill children neonates with admitted to SAT Hospital, a tertiary care teaching South India over period 1 year the objective assess immediate long term outcome involved adverse outcome. Adverse defined as or development CKD survivors. by pRIFLE nRIFLE criteria respectively neonates. Those pre-existing CAKUT were excluded. The demographic profile, etiology, organ dysfunction, inotrope support, mechanical ventilation, severity, need dialysis condition discharge assessed. Survivors followed up assessment blood pressure, proteinuria e GFR Schwartz formula 3 months, 6 months year. below 90 mL/min/1.73 m2 normal and/or hypertension used identify Statistical analysis done SPSS 20.0 .Chi square test discrete variables, t ANOVA quantitative variables. Univariate binary logistic regression factors affecting 155 babies- 87 68 diagnosed during period. Male Female ratio 4.1:1 new-born 1.8:1 children. Out 25.3% (22) risk, 43.7 % (38) 31 (27) had failure. Dehydration due faulty feeding lactation failure formed major cause neonatal (50.6%) septicaemia (28.7%). Of 17.7% (12), 23.5 (16) 58.8% (40) respectively. Glomerulonephritis etiology (23.5%) sepsis MODS (19.1%). Significant association found between severity both (P 0.002, P 0.00). given Table 1.View Large Image Figure ViewerDownload Hi-res image Download (PPT) 13 out expired (14.9%). 83.7% discharge. 8.6% (3/35) Injury 53% (9/17) Failure partial recovery. 74 12 lost follow died months. 4/61 babies (6.5%) developed - 11% 14.2% children, 15 (22%). Among 53 survivors, 27 (51%) – {33.3 (5/15) 80.8 (21/26)} abnormal 48 till 22.9% (11) . this 20% (3/15) 36% (8/22) Severity correlated Risk anuric AKI, MODS, dialysis, component Anuric multivariate (Table 2). 6.5% surviving episode up. Regardless all after critical illness should be monitored regularly long-term damage so that early intervention becomes possible retard progression.